Lipoprotein(a) and Genetics

Lipoprotein (a)

Lipoprotein (a) also called as lp(a) was first discovered in 1963 by Kare Berg. Genetic studies and various epidemiologic studies have identified Lp(a) as a risk factor for atherosclerotic disease such as coronary heart disease and stroke. Genetics determines the lp (a) levels in the individual.

Types of lipoproteins in blood plasma

There are several other lipoproteins in the blood stream like high density lipoprotein (HDL), low density lipoprotein (LDL), VLDL. lipoprotein (a) is one of them.

Difference between LDL cholesterol and lopoprotein (a)

Though lipoprotein (a) represents a class of plasma lipoprotein particle that has overall characteristics of the low density lipoprotein (LDL) but is distinct from LDL in physical and chemical properties.

What are the differences between low density lipoprotein (LDL) and lipoprotein (a) ? There are functional differences.  LDL cholesterol has the function of carrying the cholesterol in the blood stream to all the cells in the body. Lp (a) has no such role to play. Its function is similar to that of plasminogen.

The level of Lp (a) is an inherited genetic trait that appears to remain relatively constant for a given individual.

Gender, age and or dietary manipulations do not appear to influence lp (a) levels, but some racial differences are reported.

Lp(a) concentrations vary over one thousandfold between individuals, from < 0.2 to > 200 mg/dL. This range of concentrations is observed in all populations studied so far. The mean and median concentrations between different world populations show distinct particularities, the main being the two- to threefold higher Lp(a) plasma concentration of populations of African descent compared to Asian, Oceanic, or European populations. The general inverse correlation between apo(a) isoform size and Lp(a) plasma concentration is observed in all populations, however, mean Lp(a) associated with certain apo(a) isoforms varies between populations.

Statins lower LDL cholesterol levels but they do not lower lp (a) levels.

In a healthy person the lp (a) levels present are constant depending upon the heredity traits of the person. So, the question is why lp (a) levels rise?

Another important observation is that of Dr Linus Pauling and Matthias Rath. Lipoprotein (a) is found in primates and the guinea pig. It is not found in other animals, which have the lost the ability to synthesize ascorbate, but only rarely in the blood of other animals.

Science high lipoprotein (a) levels indicate higher risk of heart disease you should take immediate steps to lower lp (a) levels. Nutritional therapy may be appropriate for you.

The key to optimal health is providing all the nutrients to the body in adequate amount, exercise and eating an alkaline diet menu plan, which maintains the body pH slightly on the alkaline side.

Resources

http://en.wikipedia.org/wiki/Lipoprotein(a)

 
Lipoprotein (a) as emerging risk factor

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